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Cold Sensitivity in S Cervisiae Histone H2A Mutants

Status Complete
Seeking Researchers No
Start Date 09/01/2006
End Date 06/30/2007
Funding Source Undergraduate Research Grants
Funding Amount
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Last Updated 07/05/2008 01:25AM
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Faculty
  Jocelyn Krebs

Student Researchers
  Alison Eshenower

Abstract

The regulation of gene expression in DNA occurs in the highly compacted structure known as chromatin.  Chromatin is composed of DNA wrapped around a histone octomer containing two copies of each of the H2A, H2B, H3, H4 histones.  Any mutation of a specific histone, such as H2A, will alter the folding of chromatin and have an effect on the expression of genes in the cell, especially under conditions of stress such as cold shock.  The yeast Saccharomyces cerevisiae, commonly used in fermentation and baking, is a powerful model organism in which to study responses to stress.  Stress responses are highly conserved from yeast to humans, so understanding how yeast cells cope with cold shock and freezing will be relevant to our understanding of how many species cope with low temperatures.

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