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Undergraduate Research Project Management System

Measuring the Induction of the Heat Shock Response

Status Complete
Seeking Researchers No
Start Date 12/01/2012
End Date 07/01/2013
Funding Source Alaska Heart Institute
Funding Amount
Community Partner
Related Course
Last Updated 01/29/2013 03:57PM
Keywords polyQ aggregation, heat shock proteins

People

Faculty
  Ben Harrison

Student Researchers
  Ann Jennings

Abstract

Research on neurological disorders such as Huntington's and Alzheimer's disease have shown that these disorders all share the common presence of D.'A that encodes proteins with long repetitive strands of the amino acid glutamine (polyglutamine; polyQ). These repetitive polyQ proteins arc expressed in neurons, and form aggregates (clumps) in cells, which cause neurological dysfunction and shorten sunial rates of those with this genetic disorder. (Warrick ct al.. 1998; Faber ct al.. 1999). Polyglutamine proteins have been studied in many model organisms including yeast, bacteria, worms, flies and mammals; and in all cases, polyQ proteins show more tendency to aggregate as the length of the polyQ region increases (Snell ct al. 1993). Arabidopsis thaliana. a plant model organism, also shows length dependent polyQ aggregation. All organisms studied to this point respond to misfolded protein (aggregates) through the expression of heat shock proteins (Mittler ct. al. 2012).

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